![tastefullyoffensive:
[via]
That’s so Jacked!!!](http://25.media.tumblr.com/19a750b7c91b4e8b5f3000c9e72c7ad2/tumblr_mogskn6x1O1qewacoo1_r1_500.jpg)
![tastefullyoffensive:
[njneal17]](http://24.media.tumblr.com/47360bccb8ce52a3664daf1795f8a1a6/tumblr_moavfawiwi1qewacoo1_500.jpg)
![tastefullyoffensive:
Meanwhile, in Turkey… [via]](http://25.media.tumblr.com/1b1b975401d4ffc3bd180fa1306c0474/tumblr_moctvxzvts1qewacoo1_r1_500.jpg)
TEARS!!!! 😂😭😂😭😂😭😂😂😭😂😂😭😂😭😂😭😂😂 @shari_amor @sheliseleona @zoesmilez24 @misslawyerladii @afronique_tee #natural #naturalhair #twistouts #thestruggleisreal
Oncogene Mutation Hijacks Splicing Process to Promote Growth and Survival
An international team of researchers – led by principal investigator Paul S. Mischel, MD, a member of the Ludwig Institute for Cancer Research and professor in the Department of Pathology at the University of California, San Diego School of Medicine – has found that a singular gene mutation helps brain cancer cells to not just survive, but grow tumors rapidly by altering the splicing of genes that control cellular metabolism.
The findings are published online in the journal Cell Metabolism.
Mischel, who heads the Ludwig Institute’s molecular pathology laboratory based at UC San Diego, and colleagues focused upon a process called alternative splicing, in which a single gene encodes for multiple proteins by including or excluding different, specific regions of DNA.
Alternative splicing is a tightly regulated and normal activity in healthy cells. For Mischel and colleagues in Los Angeles, Ohio and Japan, the question was whether mutations of a gene called EGFRvIII caused differential alternative splicing in glioblastoma multiformes (GBMs), the most common and aggressive type of malignant brain tumor. Median survival after GBM diagnosis is just 15 months with standard-of care radiation and chemotherapy. Without treatment, it is less than five months.
The scientists were particularly interested in whether the EGFRvIII mutation induced alternative splicing events that resulted in deregulation of normal cellular metabolism. “We focused on the ‘Warburg Effect,’ a common metabolic derangement in cancer that enables tumor cells to metabolize glucose in a way that provides both a sufficient supply of energy and a source of building blocks that can be used for growth,” Mischel said.
I have seen this little phrase pop up on the internet, and all though it appears deep or philosophical, I feel that the phrase is false.
Typically the people who I have seen repost this pic are people who are either going through a difficult time, or have faced some hardships and have yet to overcome and heal from them.
When I see this phrase, I believe the opposite of this phrase is true; That death is a beautiful lie, and that life is a painful truth.
There are a few reasons why I feel this way; First of, in death all pain experienced here on Earth is miniscule in the grand scheme of things (or pain simply ceases with life/sentience if you do not believe in an afterlife). If one believes in the afterlife (and I believe in the Judeo-Christian paradigm), then death is simply a ‘rite of passage’ to the next life, but is not a direct contributor to pain or truth.
In my opinion nothing is more true or real than life itself, because it is in life where one experiences pain and must learn, grow, and heal from it. This is where some people see death as an escape from the pain of life, however there is nothing in death that can comfort or strengthen you because it is the end. Death at most, and all that is after it, is the epilogue of life, and life determines what kind of epilogue one has.
Typically people have an aversion to pain, but pain is simply a sign that you are still living, still have potential for growth/healing/learning/strengthening, and still have a tender, beating heart. Although pain can be the best catalyst for growth, most people would rather avoid it or draw out their own stipulations about it (which is true to say about the original author of the quote).
So long story short, I feel that death is a beautiful lie and life is a painful truth; sure perhaps people may lie to you about what life and death are but that can make the truth of life all the more painful if you don’t know how learn from it.
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